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Protein phosphatase 2, regulatory subunit A, alpha (HGNC Symbol)
Entrez gene summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
P30153 [Direct mapping] Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform A8K7B7 [Target identity:100%; Query identity:100%] Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform; cDNA FLJ78455, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA; cDNA, FLJ96799, Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA
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Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000159 [protein phosphatase type 2A complex] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000188 [inactivation of MAPK activity] GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0003823 [antigen binding] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006275 [regulation of DNA replication] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006470 [protein dephosphorylation] GO:0006672 [ceramide metabolic process] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007059 [chromosome segregation] GO:0007084 [mitotic nuclear envelope reassembly] GO:0007143 [female meiotic division] GO:0008380 [RNA splicing] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0010033 [response to organic substance] GO:0010467 [gene expression] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0019932 [second-messenger-mediated signaling] GO:0030111 [regulation of Wnt signaling pathway] GO:0030155 [regulation of cell adhesion] GO:0030308 [negative regulation of cell growth] GO:0034047 [regulation of protein phosphatase type 2A activity] GO:0040008 [regulation of growth] GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein] GO:0045595 [regulation of cell differentiation] GO:0046982 [protein heterodimerization activity] GO:0051232 [meiotic spindle elongation] GO:0051306 [mitotic sister chromatid separation] GO:0051754 [meiotic sister chromatid cohesion, centromeric] GO:0070062 [extracellular exosome] GO:0070262 [peptidyl-serine dephosphorylation] GO:1903538 [regulation of meiotic cell cycle process involved in oocyte maturation] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
B3KQV6 [Direct mapping] Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; cDNA FLJ33169 fis, clone ADRGL2000384, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding] GO:0005515 [protein binding] GO:0006461 [protein complex assembly] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
