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KLF1

GENERAL INFORMATION

Gene name

 KLF1

Gene description

 Kruppel-like factor 1 (erythroid)

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Tissue enriched (spleen)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in hematopoietic cells in bone marrow and immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA051850
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 KLF1 (HGNC Symbol)

Synonyms

 EKLF

Description

 Kruppel-like factor 1 (erythroid) (HGNC Symbol)

Entrez gene summary

 This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12884423 - 12887181

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105610 (version 83.38)

Entrez gene

 10661

UniProt

 Q13351 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13351

Antibodypedia

 KLF1 antibodies

PROTEIN BROWSER
KLF1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLF1-001
ENSP00000264834
ENST00000264834
Q13351 [Direct mapping]
Krueppel-like factor 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0000790 [nuclear chromatin]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030218 [erythrocyte differentiation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:1901653 [cellular response to peptide]
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 362 aa
38.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.