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DNASE2

GENERAL INFORMATION

Gene name

 DNASE2

Gene description

 Deoxyribonuclease II, lysosomal

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA066185
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DNASE2 (HGNC Symbol)

Synonyms

 DNL, DNL2

Description

 Deoxyribonuclease II, lysosomal (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12875211 - 12881468

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105612 (version 83.38)

Entrez gene

 1777

UniProt

 O00115 (UniProt - Evidence at protein level)

neXtProt

 NX_O00115

Antibodypedia

 DNASE2 antibodies

PROTEIN BROWSER
DNASE2-001
DNASE2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNASE2-001
ENSP00000222219
ENST00000222219
O00115 [Direct mapping]
Deoxyribonuclease-2-alpha
A0A024R7F4 [Target identity:100%; Query identity:100%]
Deoxyribonuclease II, lysosomal, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0003677 [DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0004531 [deoxyribonuclease II activity]
GO:0005764 [lysosome]
GO:0006259 [DNA metabolic process]
GO:0006308 [DNA catabolic process]
GO:0006309 [apoptotic DNA fragmentation]
GO:0030218 [erythrocyte differentiation]
GO:0070062 [extracellular exosome]
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 360 aa
39.6 kDa 		Yes 0
DNASE2-002
ENSP00000466912
ENST00000592506
K7ENE5 [Direct mapping]
Deoxyribonuclease-2-alpha
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004531 [deoxyribonuclease II activity]
GO:0006259 [DNA metabolic process]
GO:0006309 [apoptotic DNA fragmentation]
Show all
 218 aa
24.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.