Tissue expression of KCNN1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNN1
Gene description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (hippocampus, cerebral cortex, caudate)
FANTOM5:	Group enriched (hippocampus, brain, caudate, cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, cerebral cortex, caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, brain, caudate, cerebellum)

GENE INFORMATION
Gene name	KCNN1 (HGNC Symbol)
Synonyms	hSK1, KCa2.1
Description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 (HGNC Symbol)
Entrez gene summary	Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17951293 - 18000080
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105642 (version 83.38)
Entrez gene	3780
UniProt	Q92952 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92952
Antibodypedia	KCNN1 antibodies

PROTEIN BROWSER

KCNN1-001	KCNN1-004	KCNN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNN1-001 ENSP00000476519 ENST00000222249	Q92952 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0046982 [protein heterodimerization activity] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60 kDa	No	5
KCNN1-004 ENSP00000477114 ENST00000609922	V9GYV2 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Predicted intracellular proteins Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	158 aa 16.2 kDa	No	0
KCNN1-201 ENSP00000484926 ENST00000615435	A0A087X2E7 [Direct mapping] Small conductance calcium-activated potassium channel protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60 kDa	No	5