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PIK3R2

GENERAL INFORMATION

Gene name

 PIK3R2

Gene description

 Phosphoinositide-3-kinase, regulatory subunit 2 (beta)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA069291
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PIK3R2 (HGNC Symbol)

Synonyms

 p85, P85B

Description

 Phosphoinositide-3-kinase, regulatory subunit 2 (beta) (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18153118 - 18170540

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105647 (version 83.38)

Entrez gene

 5296

UniProt

 O00459 (UniProt - Evidence at protein level)

neXtProt

 NX_O00459

Antibodypedia

 PIK3R2 antibodies

PROTEIN BROWSER
PIK3R2-001
PIK3R2-201
PIK3R2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3R2-001
ENSP00000222254
ENST00000222254
O00459 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010506 [regulation of autophagy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0019903 [protein phosphatase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 728 aa
81.5 kDa 		No 0
PIK3R2-201
ENSP00000477864
ENST00000617130
O00459 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010506 [regulation of autophagy]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0019903 [protein phosphatase binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 728 aa
81.5 kDa 		No 0
PIK3R2-202
ENSP00000484714
ENST00000617642
E9PFP1 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 481 aa
52.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.