Cell atlas - ISYNA1 - The Human Protein Atlas

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ISYNA1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ISYNA1
Gene description	Inositol-3-phosphate synthase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)
Mouse	Localized to the Nucleus in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007931
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007931	A-431	Nucleus
	HPA007931	A-431	Cytosol
	HPA007931	HEK 293	Nucleus
	HPA007931	HEK 293	Cytosol
	HPA007931	U-2 OS	Nucleus
	HPA007931	U-2 OS	Cytosol

MOUSE CELLS

Main location

Nucleus

Mouse gene

ENSMUSG00000019139 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA007931	NIH 3T3	Nucleus

GENE INFORMATION
Gene name	ISYNA1 (HGNC Symbol)
Synonyms	Ino1, INOS, IPS
Description	Inositol-3-phosphate synthase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18434388 - 18438301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105655 (version 83.38)
Entrez gene	51477
UniProt	Q9NPH2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPH2
Antibodypedia	ISYNA1 antibodies

PROTEIN BROWSER

ISYNA1-001	ISYNA1-002	ISYNA1-006	ISYNA1-009	ISYNA1-010	ISYNA1-011	ISYNA1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISYNA1-001 ENSP00000415458 ENST00000457269	Q9NPH2 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	Enzymes ENZYME proteins Isomerase SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	504 aa 55.1 kDa	No	0
ISYNA1-002 ENSP00000337746 ENST00000338128	Q9NPH2 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	Enzymes ENZYME proteins Isomerase SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	558 aa 61.1 kDa	No	0
ISYNA1-006 ENSP00000475677 ENST00000578963	Q9NPH2 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	Enzymes ENZYME proteins Isomerase SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	430 aa 47.1 kDa	No	0
ISYNA1-009 ENSP00000464430 ENST00000583534	J3QRY0 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] Show all	148 aa 16.1 kDa	No	0
ISYNA1-010 ENSP00000463500 ENST00000581800	J3QLD7 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] Show all	183 aa 19.5 kDa	No	0
ISYNA1-011 ENSP00000464528 ENST00000581672	J3QS51 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] Show all	233 aa 25.2 kDa	No	0
ISYNA1-012 ENSP00000462001 ENST00000578352	J3KRH4 [Direct mapping] Inositol-3-phosphate synthase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004512 [inositol-3-phosphate synthase activity] GO:0006021 [inositol biosynthetic process] GO:0008654 [phospholipid biosynthetic process] Show all	177 aa 19.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.