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COMP

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GENERAL INFORMATION

Gene name

 COMP

Gene description

 Cartilage oligomeric matrix protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BJ, Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 COMP (HGNC Symbol)

Synonyms

 EDM1, EPD1, MED, PSACH, THBS5

Description

 Cartilage oligomeric matrix protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18782773 - 18791314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105664 (version 83.38)

Entrez gene

 1311

UniProt

 P49747 (UniProt - Evidence at protein level)

neXtProt

 NX_P49747

Antibodypedia

 COMP antibodies

PROTEIN BROWSER
COMP-001
COMP-005
COMP-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COMP-001
ENSP00000222271
ENST00000222271
P49747 [Direct mapping]
Cartilage oligomeric matrix protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0002020 [protease binding]
GO:0003417 [growth plate cartilage development]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0008201 [heparin binding]
GO:0009887 [organ morphogenesis]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0043066 [negative regulation of apoptotic process]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0060173 [limb development]
GO:0070062 [extracellular exosome]
Show all
 757 aa
82.9 kDa 		Yes 0
COMP-005
ENSP00000403792
ENST00000425807
P49747 [Direct mapping]
Cartilage oligomeric matrix protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0002020 [protease binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0007155 [cell adhesion]
GO:0008201 [heparin binding]
GO:0009887 [organ morphogenesis]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0043066 [negative regulation of apoptotic process]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0060173 [limb development]
GO:0070062 [extracellular exosome]
Show all
 704 aa
77.2 kDa 		Yes 0
COMP-007
ENSP00000439156
ENST00000542601
G3XAP6 [Direct mapping]
Cartilage oligomeric matrix protein; Cartilage oligomeric matrix protein, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
Show all
 724 aa
79.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.