Expression of COPE in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Coatomer protein complex, subunit epsilon

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041605	HPA043576	CAB034345

GENE INFORMATION
Gene name	COPE (HGNC Symbol)
Synonyms	epsilon-COP
Description	Coatomer protein complex, subunit epsilon (HGNC Symbol)
Entrez gene summary	The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18899514 - 18919397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105669 (version 83.38)
Entrez gene	11316
UniProt	O14579 (UniProt - Evidence at protein level)
neXtProt	NX_O14579
Antibodypedia	COPE antibodies

PROTEIN BROWSER

COPE-001	COPE-002	COPE-004	COPE-005	COPE-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COPE-001 ENSP00000262812 ENST00000262812	O14579 [Direct mapping] Coatomer subunit epsilon Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0015031 [protein transport] GO:0030126 [COPI vesicle coat] GO:0030137 [COPI-coated vesicle] GO:0048205 [COPI coating of Golgi vesicle] GO:0061024 [membrane organization] Show all	308 aa 34.5 kDa	No	0
COPE-002 ENSP00000345674 ENST00000351079	O14579 [Direct mapping] Coatomer subunit epsilon Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0015031 [protein transport] GO:0030126 [COPI vesicle coat] GO:0048205 [COPI coating of Golgi vesicle] GO:0061024 [membrane organization] Show all	257 aa 28.8 kDa	No	0
COPE-004 ENSP00000469035 ENST00000600932	M0QXB4 [Direct mapping] Coatomer protein complex, subunit epsilon, isoform CRA_g; Coatomer subunit epsilon Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0030126 [COPI vesicle coat] Show all	331 aa 36.9 kDa	No	0
COPE-005 ENSP00000343134 ENST00000349893	O14579 [Direct mapping] Coatomer subunit epsilon Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0015031 [protein transport] GO:0030126 [COPI vesicle coat] GO:0048205 [COPI coating of Golgi vesicle] GO:0061024 [membrane organization] Show all	256 aa 28.8 kDa	No	0
COPE-201 ENSP00000483420 ENST00000614388	A0A087X0I4 [Direct mapping] Coatomer subunit epsilon Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0030126 [COPI vesicle coat] Show all	307 aa 34.5 kDa	No	0