Cell atlas - TMEM59L - The Human Protein Atlas

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TMEM59L

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleoplasm

Human cell
	Actin Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TMEM59L
Gene description	Transmembrane protein 59-like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments. In addition localized to the nucleoplasm.
RNA cell category	Group enriched (AN3-CA, EFO-21, SH-SY5Y, Hep G2, U-2 OS)
Protein evidence	Evidence at transcript level
Main location	Localized to the Actin filaments (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA070701
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (AN3-CA, EFO-21, SH-SY5Y, Hep G2, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments. In addition localized to the nucleoplasm.

Main location

Actin filaments (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070701	Hep G2	Nucleoplasm
	HPA070701	Hep G2	Actin filaments
	HPA070701	SH-SY5Y	Actin filaments
	HPA070701	U-2 OS	Actin filaments

GENE INFORMATION
Gene name	TMEM59L (HGNC Symbol)
Synonyms	BSMAP, C19orf4
Description	Transmembrane protein 59-like (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18607430 - 18621039
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000105696 (version 83.38)
Entrez gene	25789
UniProt	Q9UK28 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UK28
Antibodypedia	TMEM59L antibodies

PROTEIN BROWSER

TMEM59L-001	TMEM59L-005	TMEM59L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM59L-001 ENSP00000470879 ENST00000600490	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1
TMEM59L-005 ENSP00000471612 ENST00000594709	M0R134 [Direct mapping] Transmembrane protein 59-like Show all	Predicted intracellular proteins Show all		134 aa 14.3 kDa	No	0
TMEM59L-201 ENSP00000262817 ENST00000262817	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.