Cell atlas - FKBP8 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FKBP8
Gene description	FK506 binding protein 8, 38kDa
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the cytosol & endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Endoplasmic reticulum (supported), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB025346 , HPA045177
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the cytosol & endoplasmic reticulum.

Main location

Mitochondria (supported)

Additional location

Endoplasmic reticulum (supported), Cytosol (supported)


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Antibody	Cell line	Location	Single-cell variation
CAB025346	A-431	Mitochondria
CAB025346	U-2 OS	Mitochondria
CAB025346	U-251 MG	Mitochondria	Intensity
HPA045177	A-431	Mitochondria
HPA045177	A-431	Cytosol
HPA045177	U-2 OS	Endoplasmic reticulum
HPA045177	U-2 OS	Mitochondria
HPA045177	U-251 MG	Mitochondria
HPA045177	U-251 MG	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000019428 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA045177	NIH 3T3	No staining

GENE INFORMATION
Gene name	FKBP8 (HGNC Symbol)
Synonyms	FKBP38, FKBPr38
Description	FK506 binding protein 8, 38kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18531751 - 18544077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105701 (version 83.38)
Entrez gene	23770
UniProt	Q14318 (UniProt - Evidence at protein level)
neXtProt	NX_Q14318
Antibodypedia	FKBP8 antibodies

PROTEIN BROWSER

FKBP8-001	FKBP8-002	FKBP8-004	FKBP8-006	FKBP8-007	FKBP8-008	FKBP8-009	FKBP8-011	FKBP8-013	FKBP8-014	FKBP8-015	FKBP8-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP8-001 ENSP00000471700 ENST00000597960	Q14318 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016032 [viral process] GO:0031966 [mitochondrial membrane] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0061077 [chaperone-mediated protein folding] Show all	413 aa 44.6 kDa	No	1
FKBP8-002 ENSP00000472302 ENST00000596558	Q14318 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 A0A024R7P2 [Target identity:100%; Query identity:100%] FK506 binding protein 8, 38kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016032 [viral process] GO:0031966 [mitochondrial membrane] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0061077 [chaperone-mediated protein folding] Show all	412 aa 44.6 kDa	No	1
FKBP8-004 ENSP00000441267 ENST00000544835	A0A0A0MTJ1 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	249 aa 27.1 kDa	No	1
FKBP8-006 ENSP00000472643 ENST00000597611	M0R2K9 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	257 aa 27.5 kDa	No	0
FKBP8-007 ENSP00000472087 ENST00000594844	M0R1S6 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	168 aa 17.9 kDa	No	0
FKBP8-008 ENSP00000472731 ENST00000599540	M0R2Q6 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	204 aa 21.8 kDa	No	0
FKBP8-009 ENSP00000472043 ENST00000597547	M0R1Q0 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	163 aa 17.4 kDa	No	0
FKBP8-011 ENSP00000475588 ENST00000596015	U3KQ64 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0061077 [chaperone-mediated protein folding] Show all	182 aa 19.9 kDa	No	1
FKBP8-013 ENSP00000477278 ENST00000609656	V9GZ05 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	23 aa 2.3 kDa	No	0
FKBP8-014 ENSP00000476767 ENST00000608443	Q14318 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0001708 [cell fate specification] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006915 [apoptotic process] GO:0007224 [smoothened signaling pathway] GO:0009953 [dorsal/ventral pattern formation] GO:0010468 [regulation of gene expression] GO:0016020 [membrane] GO:0016032 [viral process] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021915 [neural tube development] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030510 [regulation of BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0031966 [mitochondrial membrane] GO:0035264 [multicellular organism growth] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0061077 [chaperone-mediated protein folding] Show all	413 aa 44.6 kDa	No	1
FKBP8-015 ENSP00000475895 ENST00000606531	U3KQI1 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	103 aa 11 kDa	No	0
FKBP8-016 ENSP00000222308 ENST00000222308	Q14318 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP8 A0A024R7P2 [Target identity:100%; Query identity:100%] FK506 binding protein 8, 38kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016032 [viral process] GO:0031966 [mitochondrial membrane] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0061077 [chaperone-mediated protein folding] Show all	412 aa 44.6 kDa	No	1