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HPN

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GENERAL INFORMATION

Gene name

 HPN

Gene description

 Hepsin

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (Hep G2, EFO-21, T-47d)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Hep G2, EFO-21, T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HPN (HGNC Symbol)

Synonyms

 TMPRSS1

Description

 Hepsin (HGNC Symbol)

Entrez gene summary

 This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 19

Cytoband

 q13.11

Chromosome location (bp)

 35040506 - 35066571

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105707 (version 83.38)

Entrez gene

 3249

UniProt

 P05981 (UniProt - Evidence at protein level)

neXtProt

 NX_P05981

Antibodypedia

 HPN antibodies

PROTEIN BROWSER
HPN-001
HPN-002
HPN-005
HPN-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HPN-001
ENSP00000376060
ENST00000392226
P05981 [Direct mapping]
Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010756 [positive regulation of plasminogen activation]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0031965 [nuclear membrane]
GO:0034769 [basement membrane disassembly]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043923 [positive regulation by host of viral transcription]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0070008 [serine-type exopeptidase activity]
GO:0070062 [extracellular exosome]
GO:0071805 [potassium ion transmembrane transport]
GO:0090103 [cochlea morphogenesis]
GO:0097066 [response to thyroid hormone]
GO:0097195 [pilomotor reflex]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000611 [positive regulation of thyroid hormone generation]
Show all
 417 aa
45 kDa 		No 1
HPN-002
ENSP00000262626
ENST00000262626
P05981 [Direct mapping]
Serine protease hepsin Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006508 [proteolysis]
GO:0007605 [sensory perception of sound]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010756 [positive regulation of plasminogen activation]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030307 [positive regulation of cell growth]
GO:0031965 [nuclear membrane]
GO:0034769 [basement membrane disassembly]
GO:0042632 [cholesterol homeostasis]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043923 [positive regulation by host of viral transcription]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0070008 [serine-type exopeptidase activity]
GO:0070062 [extracellular exosome]
GO:0071805 [potassium ion transmembrane transport]
GO:0090103 [cochlea morphogenesis]
GO:0097066 [response to thyroid hormone]
GO:0097195 [pilomotor reflex]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000611 [positive regulation of thyroid hormone generation]
Show all
 417 aa
45 kDa 		No 1
HPN-005
ENSP00000470327
ENST00000597419
M0QZ63 [Direct mapping]
Serine protease hepsin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0070008 [serine-type exopeptidase activity]
Show all
 259 aa
28.1 kDa 		No 0
HPN-007
ENSP00000472310
ENST00000600390
M0R244 [Direct mapping]
Serine protease hepsin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
GO:0070008 [serine-type exopeptidase activity]
Show all
 80 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.