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SCN1B

GENERAL INFORMATION

Gene name

 SCN1B

Gene description

 Sodium channel, voltage gated, type I beta subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SCN1B

Synonyms

Description

 Sodium channel, voltage gated, type I beta subunit (HGNC Symbol)

Entrez gene summary

 Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Chromosome

 19

Cytoband

 q13.11

Chromosome location (bp)

 35030684 - 35040448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105711 (version 83.38)

Entrez gene

 6324

UniProt

 Q07699 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07699

Antibodypedia

 SCN1B antibodies

PROTEIN BROWSER
SCN1B-001
SCN1B-002
SCN1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCN1B-001
ENSP00000262631
ENST00000262631
Q07699 [Direct mapping]
Sodium channel subunit beta-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010976 [positive regulation of neuron projection development]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0019227 [neuronal action potential propagation]
GO:0019871 [sodium channel inhibitor activity]
GO:0021966 [corticospinal neuron axon guidance]
GO:0030315 [T-tubule]
GO:0033268 [node of Ranvier]
GO:0035725 [sodium ion transmembrane transport]
GO:0040011 [locomotion]
GO:0051899 [membrane depolarization]
GO:0060048 [cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0061337 [cardiac conduction]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086047 [membrane depolarization during Purkinje myocyte cell action potential]
GO:0086062 [voltage-gated sodium channel activity involved in Purkinje myocyte action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 218 aa
24.7 kDa 		Yes 1
SCN1B-002
ENSP00000468848
ENST00000595652
B4DI92 [Direct mapping]
Sodium channel subunit beta-1; cDNA FLJ55064, moderately similar to Sodium channel beta-1 subunit
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0006814 [sodium ion transport]
GO:0017080 [sodium channel regulator activity]
Show all
 147 aa
16.2 kDa 		Yes 1
SCN1B-003
ENSP00000396915
ENST00000415950
Q07699 [Direct mapping]
Sodium channel subunit beta-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0002028 [regulation of sodium ion transport]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010976 [positive regulation of neuron projection development]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0019227 [neuronal action potential propagation]
GO:0019871 [sodium channel inhibitor activity]
GO:0021966 [corticospinal neuron axon guidance]
GO:0030315 [T-tubule]
GO:0033268 [node of Ranvier]
GO:0034706 [sodium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0040011 [locomotion]
GO:0046684 [response to pyrethroid]
GO:0051899 [membrane depolarization]
GO:0060048 [cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0061337 [cardiac conduction]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086047 [membrane depolarization during Purkinje myocyte cell action potential]
GO:0086062 [voltage-gated sodium channel activity involved in Purkinje myocyte action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 268 aa
30.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.