Expression of ETHE1 in cancer - Summary

CANCER ATLAS

Gene description

Ethylmalonic encephalopathy 1

Protein class

Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028360	HPA029028	HPA029029

GENE INFORMATION
Gene name	ETHE1 (HGNC Symbol)
Synonyms	HSCO, YF13H12
Description	Ethylmalonic encephalopathy 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a sulfur dioxygenase that localizes within the mitochondrial matrix. The enzyme functions in sulfide catabolism. Mutations in this gene result in ethylmalonic encephalopathy.[provided by RefSeq, May 2009]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43506719 - 43527244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105755 (version 83.38)
Entrez gene	23474
UniProt	O95571 (UniProt - Evidence at protein level)
neXtProt	NX_O95571
Antibodypedia	ETHE1 antibodies

PROTEIN BROWSER

ETHE1-001	ETHE1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETHE1-001 ENSP00000292147 ENST00000292147	O95571 [Direct mapping] Persulfide dioxygenase ETHE1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0005506 [iron ion binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006749 [glutathione metabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0050313 [sulfur dioxygenase activity] GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase] GO:0070813 [hydrogen sulfide metabolic process] Show all	254 aa 27.9 kDa	No	0
ETHE1-004 ENSP00000469037 ENST00000600651	M0QXB5 [Direct mapping] Persulfide dioxygenase ETHE1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] Show all	260 aa 28.4 kDa	No	0