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PMPCB

GENERAL INFORMATION

Gene name

 PMPCB

Gene description

 Peptidase (mitochondrial processing) beta

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040674
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PMPCB (HGNC Symbol)

Synonyms

 MPPB, MPPP52

Description

 Peptidase (mitochondrial processing) beta (HGNC Symbol)

Entrez gene summary

 This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 103297422 - 103329511

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105819 (version 83.38)

Entrez gene

 9512

UniProt

 O75439 (UniProt - Evidence at protein level)

neXtProt

 NX_O75439

Antibodypedia

 PMPCB antibodies

PROTEIN BROWSER
PMPCB-001
PMPCB-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PMPCB-001
ENSP00000249269
ENST00000249269
O75439 [Direct mapping]
Mitochondrial-processing peptidase subunit beta
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005750 [mitochondrial respiratory chain complex III]
GO:0005759 [mitochondrial matrix]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006508 [proteolysis]
GO:0006626 [protein targeting to mitochondrion]
GO:0008270 [zinc ion binding]
GO:0009060 [aerobic respiration]
GO:0016485 [protein processing]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
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 489 aa
54.4 kDa 		No 0
PMPCB-007
ENSP00000390035
ENST00000428154
G3V0E4 [Direct mapping]
Mitochondrial-processing peptidase subunit beta; Peptidase (Mitochondrial processing) beta, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
Show all
 490 aa
54.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.