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PIK3CG

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GENERAL INFORMATION

Gene name

 PIK3CG

Gene description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (U-266/70, MOLT-4, U-937)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA069976
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, MOLT-4, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA069976 HUVEC TERT2 Plasma membrane

GENE INFORMATION

Gene name

 PIK3CG

Synonyms

Description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (HGNC Symbol)

Entrez gene summary

 Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 106865278 - 106907145

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105851 (version 83.38)

Entrez gene

 5294

UniProt

 P48736 (UniProt - Evidence at protein level)

neXtProt

 NX_P48736

Antibodypedia

 PIK3CG antibodies

PROTEIN BROWSER
PIK3CG-001
PIK3CG-002
PIK3CG-003
PIK3CG-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3CG-001
ENSP00000392258
ENST00000440650
P48736 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
A0A024R720 [Target identity:100%; Query identity:100%]
Phosphoinositide-3-kinase, catalytic, gamma polypeptide, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001816 [cytokine production]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002679 [respiratory burst involved in defense response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006897 [endocytosis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0010818 [T cell chemotaxis]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035747 [natural killer cell chemotaxis]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055118 [negative regulation of cardiac muscle contraction]
GO:0070527 [platelet aggregation]
GO:0072672 [neutrophil extravasation]
Show all
 1102 aa
126.5 kDa 		No 0
PIK3CG-002
ENSP00000419260
ENST00000496166
P48736 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
A0A024R720 [Target identity:100%; Query identity:100%]
Phosphoinositide-3-kinase, catalytic, gamma polypeptide, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001816 [cytokine production]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002679 [respiratory burst involved in defense response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006897 [endocytosis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0010818 [T cell chemotaxis]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035747 [natural killer cell chemotaxis]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055118 [negative regulation of cardiac muscle contraction]
GO:0070527 [platelet aggregation]
GO:0072672 [neutrophil extravasation]
Show all
 1102 aa
126.5 kDa 		No 0
PIK3CG-003
ENSP00000352121
ENST00000359195
P48736 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
A0A024R720 [Target identity:100%; Query identity:100%]
Phosphoinositide-3-kinase, catalytic, gamma polypeptide, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001816 [cytokine production]
GO:0001932 [regulation of protein phosphorylation]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002679 [respiratory burst involved in defense response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006897 [endocytosis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007596 [blood coagulation]
GO:0010818 [T cell chemotaxis]
GO:0010897 [negative regulation of triglyceride catabolic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0030593 [neutrophil chemotaxis]
GO:0032252 [secretory granule localization]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035747 [natural killer cell chemotaxis]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0042629 [mast cell granule]
GO:0043085 [positive regulation of catalytic activity]
GO:0043303 [mast cell degranulation]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055118 [negative regulation of cardiac muscle contraction]
GO:0070527 [platelet aggregation]
GO:0071320 [cellular response to cAMP]
GO:0072672 [neutrophil extravasation]
GO:0097284 [hepatocyte apoptotic process]
GO:1903169 [regulation of calcium ion transmembrane transport]
GO:2000270 [negative regulation of fibroblast apoptotic process]
Show all
 1102 aa
126.5 kDa 		No 0
PIK3CG-004
ENSP00000417623
ENST00000473541
E9PDN7 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0048015 [phosphatidylinositol-mediated signaling]
Show all
 182 aa
20.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.