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Weak to moderate cytoplasmic or membranous staining in several cases of colorectal, breast, cervical, endometrial, lung, urothelial, pancreatic and liver cancers. Other cancer tissues were negative.
A few cases of hepatocellular carcinomas, adenocarcinomas in lung, colorectal and breast cancers showed moderate cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
PON3
Synonyms
Description
Paraoxonase 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]