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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PTN
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PTN

Gene description

Pleiotrophin

Protein class

Cancer-related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
CAB017685
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PTN (HGNC Symbol)

Synonyms

HBGF8, HBNF, NEGF1

Description

Pleiotrophin (HGNC Symbol)

Entrez gene summary

Chromosome

7

Cytoband

q33

Chromosome location (bp)

137227341 - 137343865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105894 (version 83.38)

Entrez gene

5764

UniProt

P21246 (UniProt - Evidence at protein level)

neXtProt

NX_P21246

Antibodypedia

PTN antibodies

PROTEIN BROWSER

PTN-001
PTN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTN-001
ENSP00000341170
ENST00000348225
P21246 [Direct mapping]
Pleiotrophin
A0A024R778 [Target identity:100%; Query identity:100%]
Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001889 [liver development]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007612 [learning]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0010976 [positive regulation of neuron projection development]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0021510 [spinal cord development]
GO:0021549 [cerebellum development]
GO:0021794 [thalamus development]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030902 [hindbrain development]
GO:0031594 [neuromuscular junction]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0034644 [cellular response to UV]
GO:0035373 [chondroitin sulfate proteoglycan binding]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038085 [vascular endothelial growth factor binding]
GO:0042493 [response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043394 [proteoglycan binding]
GO:0044849 [estrous cycle]
GO:0045446 [endothelial cell differentiation]
GO:0045837 [negative regulation of membrane potential]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0060041 [retina development in camera-type eye]
GO:0060221 [retinal rod cell differentiation]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060291 [long-term synaptic potentiation]
GO:0071305 [cellular response to vitamin D]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
GO:1904373 [response to kainic acid]
GO:1904389 [rod bipolar cell differentiation]
GO:1904391 [response to ciliary neurotrophic factor]
GO:1904395 [positive regulation of skeletal muscle acetylcholine-gated channel clustering]
GO:1904397 [negative regulation of neuromuscular junction development]
GO:1904399 [heparan sulfate binding]
GO:1990089 [response to nerve growth factor]
GO:2000347 [positive regulation of hepatocyte proliferation]
Show all
168 aa
18.9 kDa
Yes 0
PTN-002
ENSP00000376798
ENST00000393083
C9JR52 [Direct mapping]
Pleiotrophin
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008083 [growth factor activity]
Show all
166 aa
18.9 kDa
Yes 0

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