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Moderate to strong cytoplasmic and/or membranous immunoreactivity was observed in several melanomas, skin, urothelial and renal cancers along with few embryonal carcinomas, lung, cervical and pancreatic cancers. Remaining cancer tissues were generally negative.
Melanomas and a few cases of gliomas, cervical, testicular and urothelial cancers showed moderate to strong cytoplasmic and membranous positivity. Other cancers were mainly negative.
GENE INFORMATION
Gene name
CAV1 (HGNC Symbol)
Synonyms
CAV
Description
Caveolin 1, caveolae protein, 22kDa (HGNC Symbol)
Entrez gene summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]