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HOXA3

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GENERAL INFORMATION

Gene name

 HOXA3

Gene description

 Homeobox A3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (CAPAN-2, AN3-CA, WM-115)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA029157
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, AN3-CA, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029157 A-431 Nucleoplasm
HPA029157 U-2 OS Nucleoplasm
HPA029157 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 HOXA3 (HGNC Symbol)

Synonyms

 HOX1, HOX1E

Description

 Homeobox A3 (HGNC Symbol)

Entrez gene summary

 In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p15.2

Chromosome location (bp)

 27106184 - 27152581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105997 (version 83.38)

Entrez gene

 3200

UniProt

 O43365 (UniProt - Evidence at protein level)

neXtProt

 NX_O43365

Antibodypedia

 HOXA3 antibodies

PROTEIN BROWSER
HOXA3-001
HOXA3-002
HOXA3-004
HOXA3-005
HOXA3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXA3-001
ENSP00000379640
ENST00000396352
O43365 [Direct mapping]
Homeobox protein Hox-A3
A0A024RA33 [Target identity:100%; Query identity:100%]
Homeobox A3, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 443 aa
46.4 kDa 		No 0
HOXA3-002
ENSP00000324884
ENST00000317201
O43365 [Direct mapping]
Homeobox protein Hox-A3
A0A024RA33 [Target identity:100%; Query identity:100%]
Homeobox A3, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 443 aa
46.4 kDa 		No 0
HOXA3-004
ENSP00000430566
ENST00000522456
F2Z3A4 [Direct mapping]
Homeobox protein Hox-A3
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Predicted intracellular proteins
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 54 aa
5.8 kDa 		No 0
HOXA3-005
ENSP00000429426
ENST00000522788
E5RIJ8 [Direct mapping]
Homeobox protein Hox-A3
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Predicted intracellular proteins
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GO:0005654 [nucleoplasm]
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 84 aa
8.8 kDa 		No 0
HOXA3-201
ENSP00000484411
ENST00000612286
O43365 [Direct mapping]
Homeobox protein Hox-A3
A0A024RA33 [Target identity:100%; Query identity:100%]
Homeobox A3, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001525 [angiogenesis]
GO:0001974 [blood vessel remodeling]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010159 [specification of organ position]
GO:0021615 [glossopharyngeal nerve morphogenesis]
GO:0030878 [thyroid gland development]
GO:0043565 [sequence-specific DNA binding]
GO:0048538 [thymus development]
GO:0048645 [organ formation]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0051216 [cartilage development]
GO:0060017 [parathyroid gland development]
GO:0071837 [HMG box domain binding]
Show all
 443 aa
46.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.