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All cancer tissues were weak to moderate cytoplasmic stained.
GENE INFORMATION
Gene name
HOXA5 (HGNC Symbol)
Synonyms
HOX1, HOX1C
Description
Homeobox A5 (HGNC Symbol)
Entrez gene summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0002009 [morphogenesis of an epithelium] GO:0003016 [respiratory system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007389 [pattern specification process] GO:0007585 [respiratory gaseous exchange] GO:0009952 [anterior/posterior pattern specification] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0016477 [cell migration] GO:0016525 [negative regulation of angiogenesis] GO:0030324 [lung development] GO:0030878 [thyroid gland development] GO:0033599 [regulation of mammary gland epithelial cell proliferation] GO:0035264 [multicellular organism growth] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045639 [positive regulation of myeloid cell differentiation] GO:0045647 [negative regulation of erythrocyte differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0060435 [bronchiole development] GO:0060439 [trachea morphogenesis] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060480 [lung goblet cell differentiation] GO:0060481 [lobar bronchus epithelium development] GO:0060484 [lung-associated mesenchyme development] GO:0060535 [trachea cartilage morphogenesis] GO:0060536 [cartilage morphogenesis] GO:0060574 [intestinal epithelial cell maturation] GO:0060638 [mesenchymal-epithelial cell signaling] GO:0060644 [mammary gland epithelial cell differentiation] GO:0060749 [mammary gland alveolus development] GO:0060764 [cell-cell signaling involved in mammary gland development]
