Expression of VIPR2 in cancer - Summary

CANCER ATLAS

Gene description

Vasoactive intestinal peptide receptor 2

Protein class

G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA062707

GENE INFORMATION
Gene name	VIPR2 (HGNC Symbol)
Synonyms	VPAC2, VPAC2R
Description	Vasoactive intestinal peptide receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	159028175 - 159144957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106018 (version 83.38)
Entrez gene	7434
UniProt	P41587 (UniProt - Evidence at protein level)
neXtProt	NX_P41587
Antibodypedia	VIPR2 antibodies

PROTEIN BROWSER

VIPR2-001	VIPR2-002	VIPR2-003	VIPR2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VIPR2-001 ENSP00000262178 ENST00000262178	P41587 [Direct mapping] Vasoactive intestinal polypeptide receptor 2 X5D7Q6 [Target identity:100%; Query identity:100%] Vasoactive intestinal peptide receptor 2 isoform A Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007267 [cell-cell signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0048662 [negative regulation of smooth muscle cell proliferation] Show all	438 aa 49.5 kDa	Yes	7
VIPR2-002 ENSP00000384497 ENST00000402066	C9JCP7 [Direct mapping] Vasoactive intestinal polypeptide receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	579 aa 64 kDa	Yes	7
VIPR2-003 ENSP00000366860 ENST00000377633	P41587 [Direct mapping] Vasoactive intestinal polypeptide receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	422 aa 46.8 kDa	No	7
VIPR2-004 ENSP00000402690 ENST00000421760	E9PCR5 [Direct mapping] Vasoactive intestinal polypeptide receptor 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] Show all	77 aa 8.8 kDa	Yes	0