Cell atlas - FKBP14 - The Human Protein Atlas

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FKBP14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleus

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FKBP14
Gene description	FK506 binding protein 14, 22 kDa
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleus & the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleus (approved), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA013329 , HPA026829
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleus & the Golgi apparatus.

Main location

Cytosol (approved)

Additional location

Nucleus (approved), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA013329	U-2 OS	Cytosol
	HPA013329	U-251 MG	Golgi apparatus
	HPA013329	U-251 MG	Cytosol
	HPA026829	A-431	Nucleoplasm
	HPA026829	A-431	Cytosol
	HPA026829	U-2 OS	Nucleus
			Nucleoli
			Cytosol
	HPA026829	U-251 MG	Nucleoplasm
	HPA026829	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FKBP14 (HGNC Symbol)
Synonyms	FKBP22, FLJ20731
Description	FK506 binding protein 14, 22 kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	30010587 - 30026684
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106080 (version 83.38)
Entrez gene	55033
UniProt	Q9NWM8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWM8
Antibodypedia	FKBP14 antibodies

PROTEIN BROWSER

FKBP14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP14-001 ENSP00000222803 ENST00000222803	Q9NWM8 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP14 A0A090N7V8 [Target identity:100%; Query identity:100%] FK506 binding protein 14, 22 kDa Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005509 [calcium ion binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0061077 [chaperone-mediated protein folding] Show all	211 aa 24.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.