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Most malignant cells showed weak to moderate positivity. Papillary adenocarcinomas in thyroid and few cases of urothelial cancers displayed strong cytoplasmic staining. Malignant lymphomas, lung, renal and skin cancers were negative in several cases.
Weak to moderate cytoplasmic and membranous immunoreactivity was observed in most tumors. Malignant lymphomas, gliomas, liver and testicular cancers were negative.
Several renal cancer showed strong cytoplasmic and membranous staining. Colorectal, prostate, lung, skin, liver and female genitalia cancers displayed moderate positivity in several cases. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
FAM188B (HGNC Symbol)
Synonyms
C7orf67, FLJ22374
Description
Family with sequence similarity 188, member B (HGNC Symbol)