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Cancer tissues showed moderate to strong cytoplasmic and/or membranous staining with additional nuclear positivity in few cases. Several cases of gliomas, lymphomas, testicular and renal cancers were weakly stained or negative.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001554 [luteolysis] GO:0003407 [neural retina development] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007420 [brain development] GO:0007568 [aging] GO:0008234 [cysteine-type peptidase activity] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016020 [membrane] GO:0016485 [protein processing] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0035234 [ectopic germ cell programmed cell death] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:2001235 [positive regulation of apoptotic signaling pathway]
