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Breast, lung, skin, urothelial, malignant melanomas and gynaecological cancers showed moderate to strong cytoplasmic positivity. Remaining malignancies were generally negative.
A majority of malignant cells displayed moderate to strong cytoplasmic immunoreactivity. Malignant lymphomas and most cases of renal, prostate, testicular and gastric cancers were negative.
A majority of malignant cells showed moderate to strong cytoplasmic immunoreactivity. Malignant lymphomas, gliomas, carcinoids, testicular, prostate and gastric cancers were mainly negative.
GENE INFORMATION
Gene name
HSPB1 (HGNC Symbol)
Synonyms
CMT2F, Hs.76067, Hsp25, HSP27, HSP28
Description
Heat shock 27kDa protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
P04792 [Direct mapping] Heat shock protein beta-1 V9HW43 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 102
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex] GO:0001895 [retina homeostasis] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006446 [regulation of translational initiation] GO:0006469 [negative regulation of protein kinase activity] GO:0006928 [movement of cell or subcellular component] GO:0006986 [response to unfolded protein] GO:0008426 [protein kinase C inhibitor activity] GO:0009615 [response to virus] GO:0010467 [gene expression] GO:0019901 [protein kinase binding] GO:0030018 [Z disc] GO:0032731 [positive regulation of interleukin-1 beta production] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043292 [contractile fiber] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0044822 [poly(A) RNA binding] GO:0045766 [positive regulation of angiogenesis] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2001028 [positive regulation of endothelial cell chemotaxis] GO:2001234 [negative regulation of apoptotic signaling pathway]
