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Most cancers exhibited weak to moderate cytoplasmic positivity. Additional nuclear positivity was seen in skin, pancreatic, ovarian, lung and liver cancers. Few cases of colorectal, ovarian, renal and urothelial cancers showed strong positivity. The majority of liver cancers and carcinoids were weakly stained or negative.
Most cancer cells displayed weak to moderate cytoplasmic immunoreactivity. Several gastric and pancreatic cancers were negative.
GENE INFORMATION
Gene name
PDAP1 (HGNC Symbol)
Synonyms
HASPP28, PAP, PAP1
Description
PDGFA associated protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]
Q13442 [Direct mapping] 28 kDa heat- and acid-stable phosphoprotein
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Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
