Tissue expression of CYP3A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CYP3A5
Gene description	Cytochrome P450, family 3, subfamily A, polypeptide 5
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (small intestine, duodenum, liver)
GTEx:	Tissue enhanced (liver, small intestine)
FANTOM5:	Group enriched (small intestine, liver, colon)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, duodenum, liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (small intestine, liver, colon)

GENE INFORMATION
Gene name	CYP3A5 (HGNC Symbol)
Synonyms	CP35, P450PCN3, PCN3
Description	Cytochrome P450, family 3, subfamily A, polypeptide 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99648194 - 99679998
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106258 (version 83.38)
Entrez gene	1577
UniProt	P20815 (UniProt - Evidence at protein level)
neXtProt	NX_P20815
Antibodypedia	CYP3A5 antibodies

PROTEIN BROWSER

CYP3A5-001	CYP3A5-003	CYP3A5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP3A5-001 ENSP00000222982 ENST00000222982	P20815 [Direct mapping] Cytochrome P450 3A5 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0009822 [alkaloid catabolic process] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042737 [drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] GO:0070989 [oxidative demethylation] Show all	502 aa 57.1 kDa	No	2
CYP3A5-003 ENSP00000401269 ENST00000439761	P20815 [Direct mapping] Cytochrome P450 3A5 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0009822 [alkaloid catabolic process] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0042737 [drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] GO:0070989 [oxidative demethylation] Show all	140 aa 15.8 kDa	No	1
CYP3A5-201 ENSP00000343074 ENST00000339843	Q7Z3N0 [Direct mapping] Cytochrome P450 3A5; Putative uncharacterized protein DKFZp686I18188 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	39 aa 4.4 kDa	No	0