Expression of PPP1R17 in cancer - Summary

CANCER ATLAS

Gene description

Protein phosphatase 1, regulatory subunit 17

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Ovarian cancer

STAINING SUMMARY

HPA047819

GENE INFORMATION
Gene name	PPP1R17 (HGNC Symbol)
Synonyms	C7orf16, GSBS
Description	Protein phosphatase 1, regulatory subunit 17 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	31686715 - 31708455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106341 (version 83.38)
Entrez gene	10842
UniProt	O96001 (UniProt - Evidence at protein level)
neXtProt	NX_O96001
Antibodypedia	PPP1R17 antibodies

PROTEIN BROWSER

PPP1R17-001	PPP1R17-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R17-001 ENSP00000340125 ENST00000342032	O96001 [Direct mapping] Protein phosphatase 1 regulatory subunit 17 A0A090N8N7 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0007417 [central nervous system development] GO:0010921 [regulation of phosphatase activity] GO:0019212 [phosphatase inhibitor activity] GO:0035556 [intracellular signal transduction] GO:0043086 [negative regulation of catalytic activity] Show all	155 aa 17.9 kDa	No	0
PPP1R17-002 ENSP00000386459 ENST00000409146	O96001 [Direct mapping] Protein phosphatase 1 regulatory subunit 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0007417 [central nervous system development] GO:0010921 [regulation of phosphatase activity] GO:0035556 [intracellular signal transduction] Show all	104 aa 12 kDa	No	0