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Moderate to strong cytoplasmic immunoreactivity was observed in malignant gliomas. Several cases of malignant melanomas, thyroid and colorectal cancers along with a few seminomas, squamous cell carcinomas and pancreatic cancers were moderately stained. Remaining malignant tissues were weakly stained or negative.
GENE INFORMATION
Gene name
SERPINE1 (HGNC Symbol)
Synonyms
PAI, PAI1, PLANH1
Description
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]