Cell atlas - PLOD3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PLOD3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PLOD3
Gene description	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PLOD3 (HGNC Symbol)
Synonyms	LH3
Description	Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	101205977 - 101218420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106397 (version 83.38)
Entrez gene	8985
UniProt	O60568 (UniProt - Evidence at protein level)
neXtProt	NX_O60568
Antibodypedia	PLOD3 antibodies

PROTEIN BROWSER

PLOD3-001	PLOD3-005	PLOD3-007	PLOD3-009	PLOD3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLOD3-001 ENSP00000223127 ENST00000223127	O60568 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0001886 [endothelial cell morphogenesis] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006464 [cellular protein modification process] GO:0008104 [protein localization] GO:0008475 [procollagen-lysine 5-dioxygenase activity] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0021915 [neural tube development] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030867 [rough endoplasmic reticulum membrane] GO:0031418 [L-ascorbic acid binding] GO:0032870 [cellular response to hormone stimulus] GO:0033823 [procollagen glucosyltransferase activity] GO:0042311 [vasodilation] GO:0048730 [epidermis morphogenesis] GO:0050211 [procollagen galactosyltransferase activity] GO:0055114 [oxidation-reduction process] GO:0060425 [lung morphogenesis] GO:0070062 [extracellular exosome] GO:0070831 [basement membrane assembly] Show all	738 aa 84.8 kDa	Yes	0
PLOD3-005 ENSP00000416070 ENST00000456079	C9JIX5 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.4 kDa	Yes	0
PLOD3-007 ENSP00000407551 ENST00000414785	C9JU11 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 19.1 kDa	No	0
PLOD3-009 ENSP00000407908 ENST00000421736	H7C2V1 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		270 aa 31.1 kDa	No	0
PLOD3-017 ENSP00000407555 ENST00000454310	H7C2S8 [Direct mapping] Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0008475 [procollagen-lysine 5-dioxygenase activity] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0055114 [oxidation-reduction process] Show all	264 aa 30.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.