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NRF1

GENERAL INFORMATION

Gene name

 NRF1

Gene description

 Nuclear respiratory factor 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA029329
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NRF1 (HGNC Symbol)

Synonyms

 ALPHA-PAL, EWG

Description

 Nuclear respiratory factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for ""nuclear factor (erythroid-derived 2)-like 1"" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Chromosome

 7

Cytoband

 q32.2

Chromosome location (bp)

 129611714 - 129757082

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106459 (version 83.38)

Entrez gene

 4899

UniProt

 Q16656 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16656

Antibodypedia

 NRF1 antibodies

PROTEIN BROWSER
NRF1-001
NRF1-002
NRF1-003
NRF1-005
NRF1-201
NRF1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRF1-001
ENSP00000223190
ENST00000223190
Q16656 [Direct mapping]
Nuclear respiratory factor 1
A0A024R770 [Target identity:100%; Query identity:100%]
Nuclear respiratory factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 503 aa
53.5 kDa 		No 0
NRF1-002
ENSP00000309826
ENST00000311967
Q16656 [Direct mapping]
Nuclear respiratory factor 1
A0A024R774 [Target identity:100%; Query identity:100%]
Nuclear respiratory factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 522 aa
55.7 kDa 		No 0
NRF1-003
ENSP00000376922
ENST00000393230
Q16656 [Direct mapping]
Nuclear respiratory factor 1
A0A024R770 [Target identity:100%; Query identity:100%]
Nuclear respiratory factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 503 aa
53.5 kDa 		No 0
NRF1-005
ENSP00000394877
ENST00000454688
C9JP85 [Direct mapping]
Nuclear respiratory factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 210 aa
22.8 kDa 		No 0
NRF1-201
ENSP00000342351
ENST00000353868
Q16656 [Direct mapping]
Nuclear respiratory factor 1
A0A024R774 [Target identity:100%; Query identity:100%]
Nuclear respiratory factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0031100 [organ regeneration]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051593 [response to folic acid]
GO:0051602 [response to electrical stimulus]
GO:0070062 [extracellular exosome]
Show all
 522 aa
55.7 kDa 		No 0
NRF1-202
ENSP00000376924
ENST00000393232
Q16656 [Direct mapping]
Nuclear respiratory factor 1
A0A024R770 [Target identity:100%; Query identity:100%]
Nuclear respiratory factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0042803 [protein homodimerization activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 503 aa
53.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.