Expression of TMEM106B in cancer - Summary

CANCER ATLAS

Gene description

Transmembrane protein 106B

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Thyroid cancer

STAINING SUMMARY

HPA058342

GENE INFORMATION
Gene name	TMEM106B (HGNC Symbol)
Synonyms	FLJ11273, MGC33727
Description	Transmembrane protein 106B (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p21.3
Chromosome location (bp)	12211241 - 12243367
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106460 (version 83.38)
Entrez gene	54664
UniProt	Q9NUM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUM4
Antibodypedia	TMEM106B antibodies

PROTEIN BROWSER

TMEM106B-001	TMEM106B-002	TMEM106B-004	TMEM106B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM106B-001 ENSP00000379901 ENST00000396667	Q9NUM4 [Direct mapping] Transmembrane protein 106B A0A024R9Z1 [Target identity:100%; Query identity:100%] Transmembrane protein 106B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0032418 [lysosome localization] GO:0043231 [intracellular membrane-bounded organelle] GO:0048813 [dendrite morphogenesis] GO:0070062 [extracellular exosome] Show all	274 aa 31.1 kDa	No	1
TMEM106B-002 ENSP00000379902 ENST00000396668	Q9NUM4 [Direct mapping] Transmembrane protein 106B A0A024R9Z1 [Target identity:100%; Query identity:100%] Transmembrane protein 106B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0032418 [lysosome localization] GO:0043231 [intracellular membrane-bounded organelle] GO:0048813 [dendrite morphogenesis] GO:0070062 [extracellular exosome] Show all	274 aa 31.1 kDa	No	1
TMEM106B-004 ENSP00000401302 ENST00000444443	C9JZ87 [Direct mapping] Transmembrane protein 106B Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043231 [intracellular membrane-bounded organelle] Show all	110 aa 12.2 kDa	No	0
TMEM106B-006 ENSP00000391985 ENST00000442107	C9J998 [Direct mapping] Transmembrane protein 106B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0