Tissue expression of MEST - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MEST
Gene description	Mesoderm specific transcript
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (placenta)
GTEx:	Tissue enhanced (adipose tissue)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MEST (HGNC Symbol)
Synonyms	PEG1
Description	Mesoderm specific transcript (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Chromosome	7
Cytoband	q32.2
Chromosome location (bp)	130486171 - 130506296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106484 (version 83.38)
Entrez gene	4232
UniProt	Q5EB52 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5EB52
Antibodypedia	MEST antibodies

PROTEIN BROWSER

MEST-001	MEST-002	MEST-003	MEST-004	MEST-005	MEST-006	MEST-007	MEST-008	MEST-009	MEST-011	MEST-012	MEST-017	MEST-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEST-001 ENSP00000223215 ENST00000223215	Q5EB52 [Direct mapping] Mesoderm-specific transcript homolog protein A0A024R768 [Target identity:100%; Query identity:100%] Mesoderm specific transcript homolog (Mouse); Mesoderm specific transcript homolog (Mouse), isoform CRA_b Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007498 [mesoderm development] GO:0008152 [metabolic process] GO:0010883 [regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	335 aa 38.8 kDa	No	0
MEST-002 ENSP00000342749 ENST00000341441	Q5EB52 [Direct mapping] Mesoderm-specific transcript homolog protein A4D1L9 [Target identity:100%; Query identity:100%] Mesoderm specific transcript homolog (Mouse); Mesoderm specific transcript homolog (Mouse), isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007498 [mesoderm development] GO:0008152 [metabolic process] GO:0010883 [regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	326 aa 37.6 kDa	Yes	0
MEST-003 ENSP00000408933 ENST00000416162	Q5EB52 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007498 [mesoderm development] GO:0008152 [metabolic process] GO:0010883 [regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	292 aa 33.8 kDa	Yes	0
MEST-004 ENSP00000367839 ENST00000378576	Q5EB52 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007498 [mesoderm development] GO:0008152 [metabolic process] GO:0010883 [regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	292 aa 33.8 kDa	Yes	0
MEST-005 ENSP00000401657 ENST00000437945	C9JW74 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	296 aa 34.3 kDa	No	0
MEST-006 ENSP00000409505 ENST00000427521	C9JSW2 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	232 aa 26.7 kDa	Yes	0
MEST-007 ENSP00000390589 ENST00000399874	C9JG66 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.6 kDa	Yes	0
MEST-008 ENSP00000409768 ENST00000433159	C9JRA9 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	160 aa 18.5 kDa	Yes	0
MEST-009 ENSP00000407222 ENST00000421001	C9JWU9 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	213 aa 24.4 kDa	Yes	0
MEST-011 ENSP00000393709 ENST00000437637	C9JUD2 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.6 kDa	Yes	0
MEST-012 ENSP00000396504 ENST00000458161	C9JCM6 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	169 aa 19.5 kDa	Yes	0
MEST-017 ENSP00000473492 ENST00000463263	R4GN52 [Direct mapping] Mesoderm-specific transcript homolog protein Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 20.1 kDa	No	0
MEST-201 ENSP00000376884 ENST00000393187	Q5EB52 [Direct mapping] Mesoderm-specific transcript homolog protein A4D1L9 [Target identity:100%; Query identity:100%] Mesoderm specific transcript homolog (Mouse); Mesoderm specific transcript homolog (Mouse), isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0007498 [mesoderm development] GO:0008152 [metabolic process] GO:0010883 [regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	326 aa 37.6 kDa	Yes	0