Tissue expression of AGR2 - Summary - The Human Protein Atlas

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AGR2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AGR2
Gene description	Anterior gradient 2, protein disulphide isomerase family member
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (rectum, stomach)
GTEx:	Group enriched (stomach, salivary gland, small intestine, colon, urinary bladder, prostate)
FANTOM5:	Tissue enhanced (seminal vesicle, gallbladder)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including glands in GI, and in female and male genitalia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA007912
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (rectum, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (stomach, salivary gland, small intestine, colon, urinary bladder, prostate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (seminal vesicle, gallbladder)

GENE INFORMATION
Gene name	AGR2 (HGNC Symbol)
Synonyms	AG2, HAG-2, PDIA17, XAG-2
Description	Anterior gradient 2, protein disulphide isomerase family member (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	16791811 - 16833433
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106541 (version 83.38)
Entrez gene	10551
UniProt	O95994 (UniProt - Evidence at protein level)
neXtProt	NX_O95994
Antibodypedia	AGR2 antibodies

PROTEIN BROWSER

AGR2-001	AGR2-005	AGR2-006	AGR2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGR2-001 ENSP00000391490 ENST00000419304	O95994 [Direct mapping] Anterior gradient protein 2 homolog Q4JM46 [Target identity:100%; Query identity:100%] AGR2; Anterior gradient 2 homolog (Xenopus laevis); Anterior gradient 2 homolog (Xenopus laevis), isoform CRA_a; Epididymis secretory protein Li 116 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002162 [dystroglycan binding] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0010628 [positive regulation of gene expression] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0042803 [protein homodimerization activity] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0048546 [digestive tract morphogenesis] GO:0048639 [positive regulation of developmental growth] GO:0060480 [lung goblet cell differentiation] GO:0060548 [negative regulation of cell death] GO:0070254 [mucus secretion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1903899 [positive regulation of PERK-mediated unfolded protein response] Show all	175 aa 20 kDa	Yes	0
AGR2-005 ENSP00000386025 ENST00000401412	B5MC07 [Direct mapping] Anterior gradient protein 2 homolog Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 21.4 kDa	Yes	0
AGR2-006 ENSP00000414806 ENST00000450569	H7C3Z9 [Direct mapping] Anterior gradient protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.5 kDa	No	0
AGR2-007 ENSP00000411969 ENST00000412973	C9J3E2 [Direct mapping] Anterior gradient protein 2 homolog Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 15 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.