Expression of CHCHD3 in cancer - Summary

CANCER ATLAS

Gene description

Coiled-coil-helix-coiled-coil-helix domain containing 3

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042935

GENE INFORMATION
Gene name	CHCHD3 (HGNC Symbol)
Synonyms	FLJ20420, Mic19, MINOS3, PPP1R22
Description	Coiled-coil-helix-coiled-coil-helix domain containing 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	7
Cytoband
Chromosome location (bp)	132784868 - 133082088
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106554 (version 83.38)
Entrez gene	54927
UniProt	Q9NX63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NX63
Antibodypedia	CHCHD3 antibodies

PROTEIN BROWSER

CHCHD3-001	CHCHD3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHCHD3-001 ENSP00000262570 ENST00000262570	Q9NX63 [Direct mapping] MICOS complex subunit MIC19 A4D1N4 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 3; Coiled-coil-helix-coiled-coil-helix domain containing 3, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006351 [transcription, DNA-templated] GO:0007007 [inner mitochondrial membrane organization] GO:0008053 [mitochondrial fusion] GO:0019902 [phosphatase binding] GO:0032947 [protein complex scaffold] GO:0042407 [cristae formation] GO:0061617 [MICOS complex] GO:0070062 [extracellular exosome] Show all	227 aa 26.2 kDa	No	0
CHCHD3-003 ENSP00000389297 ENST00000448878	C9JRZ6 [Direct mapping] MICOS complex subunit MIC19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	232 aa 26.7 kDa	No	0