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Most hepatocellular carcinomas and and a few stomach cancers showed strong cytoplasmic positivity. Essentially all other cancer tissues were negative. Tumor stroma was generally positive.
Majority of cancer tissues showed weak to moderate cytoplasmic positivity. Several cases of melanomas showed strong immunoreactivity. Gliomas, lymphomas, thyroid cancers along with several skin, urothelial, stomach and liver cancers were generally negative.
Cancer tissues were in general negative. A few gliomas and renal cancers showed moderate nuclear positivity.
GENE INFORMATION
Gene name
AEBP1 (HGNC Symbol)
Synonyms
ACLP
Description
AE binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
Q8IUX7 [Direct mapping] Adipocyte enhancer-binding protein 1
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Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001501 [skeletal system development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005516 [calmodulin binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0007517 [muscle organ development] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome]
