Tissue expression of LHX2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LHX2
Gene description	LIM homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, caudate, hippocampus)
FANTOM5:	Group enriched (hippocampus, retina, caudate, brain)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, caudate, hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, retina, caudate, brain)

GENE INFORMATION
Gene name	LHX2 (HGNC Symbol)
Synonyms	hLhx2, LH-2
Description	LIM homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.3
Chromosome location (bp)	124001670 - 124033301
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000106689 (version 83.38)
Entrez gene	9355
UniProt	P50458 (UniProt - Evidence at transcript level)
neXtProt	NX_P50458
Antibodypedia	LHX2 antibodies

PROTEIN BROWSER

LHX2-001	LHX2-002	LHX2-003	LHX2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHX2-001 ENSP00000362717 ENST00000373615	P50458 [Direct mapping] LIM/homeobox protein Lhx2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding] GO:0001843 [neural tube closure] GO:0001942 [hair follicle development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007420 [brain development] GO:0007498 [mesoderm development] GO:0008270 [zinc ion binding] GO:0009953 [dorsal/ventral pattern formation] GO:0021537 [telencephalon development] GO:0021772 [olfactory bulb development] GO:0021978 [telencephalon regionalization] GO:0021987 [cerebral cortex development] GO:0022008 [neurogenesis] GO:0030182 [neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045199 [maintenance of epithelial cell apical/basal polarity] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048675 [axon extension] GO:0060041 [retina development in camera-type eye] GO:2000678 [negative regulation of transcription regulatory region DNA binding] Show all	406 aa 44.4 kDa	No	0
LHX2-002 ENSP00000394978 ENST00000446480	H7C0H1 [Direct mapping] LIM/homeobox protein Lhx2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] Show all	412 aa 44.8 kDa	No	0
LHX2-003 ENSP00000476200 ENST00000488674	U3KQT5 [Direct mapping] LIM/homeobox protein Lhx2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	115 aa 12.5 kDa	No	0
LHX2-004 ENSP00000453448 ENST00000560961	H0YM35 [Direct mapping] LIM/homeobox protein Lhx2 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	147 aa 16.8 kDa	No	0