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Weak to moderate cytoplasmic and/or membranous immunoreactivity was observed in several cases of prostate, ovarian, cervical, pancreatic, liver, breast and colorectal cancers along with occasional lung and urothelial cancers. Remaining malignant cells were negative.
Several cases of pancreatic cancers along with a few cases of gastric, cervical, ovarian, prostate and urothelial cancers showed weak to moderate cytoplasmic and membranous positivity. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
CORO2A (HGNC Symbol)
Synonyms
IR10, WDR2
Description
Coronin, actin binding protein, 2A (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
