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AMBP

GENERAL INFORMATION

Gene name

 AMBP

Gene description

 Alpha-1-microglobulin/bikunin precursor

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in plasma and extracellular material, cytoplasmic expression was seen in renal tubules.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA001497 , CAB069436
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 AMBP (HGNC Symbol)

Synonyms

 EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI

Description

 Alpha-1-microglobulin/bikunin precursor (HGNC Symbol)

Entrez gene summary

 This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q32

Chromosome location (bp)

 114060127 - 114078472

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106927 (version 83.38)

Entrez gene

 259

UniProt

 P02760 (UniProt - Evidence at protein level)

neXtProt

 NX_P02760

Antibodypedia

 AMBP antibodies

PROTEIN BROWSER
AMBP-001
AMBP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMBP-001
ENSP00000265132
ENST00000265132
P02760 [Direct mapping]
Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain Trypstatin
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0007155 [cell adhesion]
GO:0007565 [female pregnancy]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016032 [viral process]
GO:0018298 [protein-chromophore linkage]
GO:0019855 [calcium channel inhibitor activity]
GO:0019862 [IgA binding]
GO:0020037 [heme binding]
GO:0030163 [protein catabolic process]
GO:0036094 [small molecule binding]
GO:0042167 [heme catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046329 [negative regulation of JNK cascade]
GO:0046904 [calcium oxalate binding]
GO:0050777 [negative regulation of immune response]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
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 352 aa
39 kDa 		Yes 0
AMBP-003
ENSP00000475149
ENST00000466610
S4R471 [Direct mapping]
Protein AMBP
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005576 [extracellular region]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0036094 [small molecule binding]
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 193 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.