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DNM1

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GENERAL INFORMATION

Gene name

 DNM1

Gene description

 Dynamin 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (A549)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA049910 , HPA061801
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049910 A549 Nucleoplasm
HPA049910 U-2 OS Nucleoplasm
HPA049910 U-251 MG Nucleoplasm
HPA061801 A549 Nucleoplasm
HPA061801 HeLa Nucleus
HPA061801 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000026825 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA049910 NIH 3T3 No staining

GENE INFORMATION

Gene name

 DNM1 (HGNC Symbol)

Synonyms

 DNM

Description

 Dynamin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128203352 - 128255248

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106976 (version 83.38)

Entrez gene

 1759

UniProt

 Q05193 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05193

Antibodypedia

 DNM1 antibodies

PROTEIN BROWSER
DNM1-001
DNM1-002
DNM1-007
DNM1-009
DNM1-010
DNM1-014
DNM1-015
DNM1-016
DNM1-017
DNM1-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNM1-001
ENSP00000362014
ENST00000372923
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001917 [photoreceptor inner segment]
GO:0002031 [G-protein coupled receptor internalization]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0007605 [sensory perception of sound]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008344 [adult locomotory behavior]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0031623 [receptor internalization]
GO:0031749 [D2 dopamine receptor binding]
GO:0032403 [protein complex binding]
GO:0042802 [identical protein binding]
GO:0043196 [varicosity]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0046983 [protein dimerization activity]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050998 [nitric-oxide synthase binding]
GO:0051262 [protein tetramerization]
GO:0051932 [synaptic transmission, GABAergic]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
GO:1901998 [toxin transport]
GO:1903423 [positive regulation of synaptic vesicle recycling]
Show all
 864 aa
97.4 kDa 		No 0
DNM1-002
ENSP00000377219
ENST00000393594
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 851 aa
95.9 kDa 		No 0
DNM1-007
ENSP00000419225
ENST00000475805
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 851 aa
95.9 kDa 		No 0
DNM1-009
ENSP00000345680
ENST00000341179
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 851 aa
96 kDa 		No 0
DNM1-010
ENSP00000420045
ENST00000486160
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 864 aa
97.3 kDa 		No 0
DNM1-014
ENSP00000486525
ENST00000628346
A0A0D9SFE4 [Direct mapping]
Dynamin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 864 aa
97.2 kDa 		No 0
DNM1-015
ENSP00000486437
ENST00000627061
A0A0D9SFB1 [Direct mapping]
Dynamin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 835 aa
94 kDa 		No 0
DNM1-016
ENSP00000487310
ENST00000627543
Q05193 [Direct mapping]
Dynamin-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007032 [endosome organization]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0019901 [protein kinase binding]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 851 aa
96 kDa 		No 0
DNM1-017
ENSP00000486770
ENST00000625457
A0A0D9SFP1 [Direct mapping]
Dynamin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 53 aa
5 kDa 		No 0
DNM1-018
ENSP00000489096
ENST00000634267
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
Show all
 856 aa
96.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.