Tissue expression of RLN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RLN2
Gene description	Relaxin 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (fallopian tube)
GTEx:	Tissue enhanced (prostate, pituitary gland, testis)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (fallopian tube)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, pituitary gland, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	RLN2 (HGNC Symbol)
Synonyms	bA12D24.1.1, bA12D24.1.2, H2, RLXH2
Description	Relaxin 2 (HGNC Symbol)
Entrez gene summary	Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	5299868 - 5304969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107014 (version 83.38)
Entrez gene	6019
UniProt	P04090 (UniProt - Evidence at protein level)
neXtProt	NX_P04090
Antibodypedia	RLN2 antibodies

PROTEIN BROWSER

RLN2-001	RLN2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RLN2-001 ENSP00000371040 ENST00000381627	P04090 [Direct mapping] Prorelaxin H2 Relaxin B chain Relaxin A chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] GO:0010628 [positive regulation of gene expression] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0048552 [regulation of metalloenzyme activity] Show all	185 aa 21 kDa	Yes	0
RLN2-002 ENSP00000399616 ENST00000416837	H0Y5M9 [Direct mapping] Prorelaxin H2 Show all	Predicted intracellular proteins Show all		68 aa 7.2 kDa	No	0