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KANK1

CANCER ATLAS

Gene description

 KN motif and ankyrin repeat domains 1

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005539

GENE INFORMATION

Gene name

 KANK1 (HGNC Symbol)

Synonyms

 ANKRD15, KANK, KIAA0172

Description

 KN motif and ankyrin repeat domains 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]

Chromosome

 9

Cytoband

 p24.3

Chromosome location (bp)

 470291 - 746106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107104 (version 83.38)

Entrez gene

 23189

UniProt

 Q14678 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14678

Antibodypedia

 KANK1 antibodies

PROTEIN BROWSER
KANK1-001
KANK1-003
KANK1-004
KANK1-005
KANK1-007
KANK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KANK1-001
ENSP00000371740
ENST00000382303
Q14678 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0010977 [negative regulation of neuron projection development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0090303 [positive regulation of wound healing]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900028 [negative regulation of ruffle assembly]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000393 [negative regulation of lamellipodium morphogenesis]
Show all
 1352 aa
147.3 kDa 		No 0
KANK1-003
ENSP00000371726
ENST00000382289
Q5W0W3 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 352 aa
38.3 kDa 		No 0
KANK1-004
ENSP00000371723
ENST00000382286
Q5W0W2 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 283 aa
30.3 kDa 		No 0
KANK1-005
ENSP00000371730
ENST00000382293
Q14678 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0010977 [negative regulation of neuron projection development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0090303 [positive regulation of wound healing]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900028 [negative regulation of ruffle assembly]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000393 [negative regulation of lamellipodium morphogenesis]
Show all
 1194 aa
129.8 kDa 		No 0
KANK1-007
ENSP00000371734
ENST00000382297
Q14678 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0010977 [negative regulation of neuron projection development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0090303 [positive regulation of wound healing]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900028 [negative regulation of ruffle assembly]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000393 [negative regulation of lamellipodium morphogenesis]
Show all
 1352 aa
147.3 kDa 		No 0
KANK1-201
ENSP00000477725
ENST00000619269
Q14678 [Direct mapping]
KN motif and ankyrin repeat domain-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008013 [beta-catenin binding]
GO:0010977 [negative regulation of neuron projection development]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0090303 [positive regulation of wound healing]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900028 [negative regulation of ruffle assembly]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000393 [negative regulation of lamellipodium morphogenesis]
Show all
 1352 aa
147.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.