Tissue expression of KCNT1 - Summary - The Human Protein Atlas

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KCNT1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KCNT1
Gene description	Potassium channel, sodium activated subfamily T, member 1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, spleen, skeletal muscle, ovary)
GTEx:	Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:	Tissue enhanced (cerebellum, caudate)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059880
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, spleen, skeletal muscle, ovary)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, caudate)

GENE INFORMATION
Gene name	KCNT1 (HGNC Symbol)
Synonyms	KCa4.1, KIAA1422, SLACK, Slo2.2
Description	Potassium channel, sodium activated subfamily T, member 1 (HGNC Symbol)
Entrez gene summary	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	135702185 - 135795508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107147 (version 83.38)
Entrez gene	57582
UniProt	Q5JUK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JUK3
Antibodypedia	KCNT1 antibodies

PROTEIN BROWSER

KCNT1-001	KCNT1-002	KCNT1-004	KCNT1-005	KCNT1-006	KCNT1-007	KCNT1-010	KCNT1-012	KCNT1-013	KCNT1-014	KCNT1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNT1-001 ENSP00000486374 ENST00000628528	Q5JUK3 [Direct mapping] Potassium channel subfamily T member 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1211 aa 137 kDa	No	7
KCNT1-002 ENSP00000360822 ENST00000371757	Q5JUK3 [Direct mapping] Potassium channel subfamily T member 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1235 aa 139.7 kDa	No	8
KCNT1-004 ENSP00000263604 ENST00000263604		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] Show all	1223 aa 137.6 kDa	No	8
KCNT1-005 ENSP00000486130 ENST00000631073	A0A0D9SEY3 [Direct mapping] Potassium channel subfamily T member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1237 aa 139.2 kDa	No	8
KCNT1-006 ENSP00000418003 ENST00000490355	C9JAX7 [Direct mapping] Potassium channel subfamily T member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1235 aa 139 kDa	No	8
KCNT1-007 ENSP00000417578 ENST00000486577	C9J9Y7 [Direct mapping] Potassium channel subfamily T member 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1217 aa 138 kDa	No	8
KCNT1-010 ENSP00000420764 ENST00000473941	C9JBV2 [Direct mapping] Potassium channel subfamily T member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0071805 [potassium ion transmembrane transport] Show all	285 aa 33.2 kDa	No	6
KCNT1-012 ENSP00000486486 ENST00000630792	A0A0D9SFC8 [Direct mapping] Potassium channel subfamily T member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1201 aa 136.3 kDa	No	8
KCNT1-013 ENSP00000419086 ENST00000491806	C9JYL2 [Direct mapping] Potassium channel subfamily T member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1216 aa 136.9 kDa	No	8
KCNT1-014 ENSP00000419007 ENST00000488444	Q5JUK3 [Direct mapping] Potassium channel subfamily T member 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1230 aa 138.3 kDa	No	8
KCNT1-015 ENSP00000417851 ENST00000487664	Q5JUK3 [Direct mapping] Potassium channel subfamily T member 1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0006813 [potassium ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	1256 aa 142 kDa	No	8

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.