Tissue expression of MPDZ - Summary - The Human Protein Atlas

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MPDZ

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MPDZ
Gene description	Multiple PDZ domain protein
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in most tissues

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 3 antibodies. HPA020255 , HPA026686 , CAB013512
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MPDZ (HGNC Symbol)
Synonyms	MUPP1
Description	Multiple PDZ domain protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	9
Cytoband	p23
Chromosome location (bp)	13105704 - 13279590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107186 (version 83.38)
Entrez gene	8777
UniProt	O75970 (UniProt - Evidence at protein level)
neXtProt	NX_O75970
Antibodypedia	MPDZ antibodies

PROTEIN BROWSER

MPDZ-001	MPDZ-002	MPDZ-003	MPDZ-007	MPDZ-009	MPDZ-010	MPDZ-011	MPDZ-014	MPDZ-015	MPDZ-016	MPDZ-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPDZ-001 ENSP00000320006 ENST00000319217	O75970 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0008022 [protein C-terminus binding] GO:0014069 [postsynaptic density] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] Show all	2070 aa 221.6 kDa	No	0
MPDZ-002 ENSP00000439807 ENST00000541718	O75970 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0007155 [cell adhesion] GO:0008022 [protein C-terminus binding] GO:0014069 [postsynaptic density] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0030425 [dendrite] GO:0031410 [cytoplasmic vesicle] GO:0042552 [myelination] GO:0043220 [Schmidt-Lanterman incisure] GO:0045211 [postsynaptic membrane] Show all	2041 aa 218.5 kDa	No	0
MPDZ-003 ENSP00000415964 ENST00000438511	A0A075B6R8 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	611 aa 63.8 kDa	No	0
MPDZ-007 ENSP00000444230 ENST00000545857	H0YGQ3 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1006 aa 106.8 kDa	No	0
MPDZ-009 ENSP00000415208 ENST00000447879	O75970 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0008022 [protein C-terminus binding] GO:0014069 [postsynaptic density] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] Show all	2037 aa 217.9 kDa	No	0
MPDZ-010 ENSP00000444151 ENST00000536827	O75970 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0008022 [protein C-terminus binding] GO:0014069 [postsynaptic density] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] Show all	2008 aa 214.8 kDa	No	0
MPDZ-011 ENSP00000446358 ENST00000546205	F5H1U9 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	2084 aa 223.1 kDa	No	0
MPDZ-014 ENSP00000444717 ENST00000538841	B7ZB24 [Direct mapping] Multiple PDZ domain protein; cDNA, FLJ79388, highly similar to Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	929 aa 98.6 kDa	No	0
MPDZ-015 ENSP00000389705 ENST00000433359	F8WDQ8 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	192 aa 21.1 kDa	No	0
MPDZ-016 ENSP00000443672 ENST00000542239	F5H8D6 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	129 aa 14.4 kDa	No	0
MPDZ-201 ENSP00000370410 ENST00000381022	O75970 [Direct mapping] Multiple PDZ domain protein Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0008022 [protein C-terminus binding] GO:0014069 [postsynaptic density] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] Show all	2037 aa 217.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.