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DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (HGNC Symbol)
Entrez gene summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0003676 [nucleic acid binding] GO:0003690 [double-stranded DNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005923 [bicellular tight junction] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0009597 [detection of virus] GO:0009615 [response to virus] GO:0010628 [positive regulation of gene expression] GO:0015629 [actin cytoskeleton] GO:0016032 [viral process] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0030334 [regulation of cell migration] GO:0032480 [negative regulation of type I interferon production] GO:0032587 [ruffle membrane] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0034344 [regulation of type III interferon production] GO:0039528 [cytoplasmic pattern recognition receptor signaling pathway in response to virus] GO:0039529 [RIG-I signaling pathway] GO:0042802 [identical protein binding] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043330 [response to exogenous dsRNA] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]