Tissue expression of APBA1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APBA1
Gene description	Amyloid beta (A4) precursor protein-binding, family A, member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	APBA1 (HGNC Symbol)
Synonyms	D9S411E, MINT1, X11
Description	Amyloid beta (A4) precursor protein-binding, family A, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.12
Chromosome location (bp)	69427530 - 69672306
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107282 (version 83.38)
Entrez gene	320
UniProt	Q02410 (UniProt - Evidence at protein level)
neXtProt	NX_Q02410
Antibodypedia	APBA1 antibodies

PROTEIN BROWSER

APBA1-001	APBA1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APBA1-001 ENSP00000265381 ENST00000265381	Q02410 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006886 [intracellular protein transport] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007399 [nervous system development] GO:0007626 [locomotory behavior] GO:0008021 [synaptic vesicle] GO:0008088 [axon cargo transport] GO:0010468 [regulation of gene expression] GO:0014047 [glutamate secretion] GO:0014051 [gamma-aminobutyric acid secretion] GO:0016020 [membrane] GO:0030165 [PDZ domain binding] GO:0032403 [protein complex binding] GO:0035264 [multicellular organism growth] GO:0043234 [protein complex] GO:0048471 [perinuclear region of cytoplasm] Show all	837 aa 92.9 kDa	No	0
APBA1-002 ENSP00000486435 ENST00000470082	A0A0D9SFA9 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0006461 [protein complex assembly] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] Show all	122 aa 13.7 kDa	No	0