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PPP3CB

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GENERAL INFORMATION

Gene name

 PPP3CB

Gene description

 Protein phosphatase 3, catalytic subunit, beta isozyme

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA008823
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA008823 PC-3 No staining    
HPA008823 U-2 OS Mitochondria
HPA008823 U-251 MG Mitochondria

GENE INFORMATION

Gene name

 PPP3CB (HGNC Symbol)

Synonyms

 CALNA2, CALNB, CNA2, PP2Bbeta

Description

 Protein phosphatase 3, catalytic subunit, beta isozyme (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q22.2

Chromosome location (bp)

 73436428 - 73496024

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107758 (version 83.38)

Entrez gene

 5532

UniProt

 P16298 (UniProt - Evidence at protein level)

neXtProt

 NX_P16298

Antibodypedia

 PPP3CB antibodies

PROTEIN BROWSER
PPP3CB-001
PPP3CB-002
PPP3CB-003
PPP3CB-201
PPP3CB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP3CB-001
ENSP00000353881
ENST00000360663
P16298 [Direct mapping]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005955 [calcineurin complex]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007165 [signal transduction]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019899 [enzyme binding]
GO:0030346 [protein phosphatase 2B binding]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0033192 [calmodulin-dependent protein phosphatase activity]
GO:0035176 [social behavior]
GO:0035690 [cellular response to drug]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048675 [axon extension]
GO:0050796 [regulation of insulin secretion]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
Show all
 524 aa
59 kDa 		No 0
PPP3CB-002
ENSP00000343147
ENST00000342558
Q5F2F8 [Direct mapping]
Serine/threonine-protein phosphatase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004721 [phosphoprotein phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016787 [hydrolase activity]
Show all
 496 aa
56 kDa 		No 0
PPP3CB-003
ENSP00000398022
ENST00000430762
Q5F2G0 [Direct mapping]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 187 aa
20.7 kDa 		No 0
PPP3CB-201
ENSP00000378305
ENST00000394828
P16298 [Direct mapping]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005955 [calcineurin complex]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007165 [signal transduction]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019899 [enzyme binding]
GO:0030346 [protein phosphatase 2B binding]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0033192 [calmodulin-dependent protein phosphatase activity]
GO:0035176 [social behavior]
GO:0035690 [cellular response to drug]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048675 [axon extension]
GO:0050796 [regulation of insulin secretion]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
Show all
 515 aa
58.1 kDa 		No 0
PPP3CB-202
ENSP00000378306
ENST00000394829
P16298 [Direct mapping]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001915 [negative regulation of T cell mediated cytotoxicity]
GO:0001946 [lymphangiogenesis]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005955 [calcineurin complex]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010468 [regulation of gene expression]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019899 [enzyme binding]
GO:0030018 [Z disc]
GO:0030217 [T cell differentiation]
GO:0030315 [T-tubule]
GO:0030346 [protein phosphatase 2B binding]
GO:0031987 [locomotion involved in locomotory behavior]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0033192 [calmodulin-dependent protein phosphatase activity]
GO:0034097 [response to cytokine]
GO:0035176 [social behavior]
GO:0035690 [cellular response to drug]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0043029 [T cell homeostasis]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048675 [axon extension]
GO:0050796 [regulation of insulin secretion]
GO:0051533 [positive regulation of NFAT protein import into nucleus]
Show all
 525 aa
59.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.