Cell atlas - TLX1 - The Human Protein Atlas

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TLX1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TLX1
Gene description	T-cell leukemia homeobox 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (K-562, SH-SY5Y, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, SH-SY5Y, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TLX1 (HGNC Symbol)
Synonyms	HOX11, TCL3
Description	T-cell leukemia homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Chromosome	10
Cytoband	q24.31
Chromosome location (bp)	101130505 - 101137789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107807 (version 83.38)
Entrez gene	3195
UniProt	P31314 (UniProt - Evidence at protein level)
neXtProt	NX_P31314
Antibodypedia	TLX1 antibodies

PROTEIN BROWSER

TLX1-001	TLX1-002	TLX1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLX1-001 ENSP00000359215 ENST00000370196	P31314 [Direct mapping] T-cell leukemia homeobox protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007417 [central nervous system development] GO:0008284 [positive regulation of cell proliferation] GO:0030182 [neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045165 [cell fate commitment] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048536 [spleen development] GO:0048645 [organ formation] Show all	330 aa 34.4 kDa	No	0
TLX1-002 ENSP00000434358 ENST00000463716	G3V1B7 [Direct mapping] T-cell leukemia homeobox protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		156 aa 15.1 kDa	No	0
TLX1-003 ENSP00000434914 ENST00000467928	P31314 [Direct mapping] T-cell leukemia homeobox protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	257 aa 26.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.