Cell atlas - NPM3 - The Human Protein Atlas

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NPM3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Nucleoli

Human cell
	Actin Filaments
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	NPM3
Gene description	Nucleophosmin/nucleoplasmin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli, cytosol & actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Actin filaments (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036295
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli, cytosol & actin filaments.

Main location

Nucleoli (approved), Actin filaments (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036295	A-431	Nucleoli
			Actin filaments
			Cytosol
	HPA036295	U-2 OS	Nucleoli
	HPA036295	U-2 OS	Cytosol
	HPA036295	U-251 MG	Nucleoli
			Actin filaments
			Cytosol

GENE INFORMATION
Gene name	NPM3
Synonyms
Description	Nucleophosmin/nucleoplasmin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	101781325 - 101783413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107833 (version 83.38)
Entrez gene	10360
UniProt	O75607 (UniProt - Evidence at protein level)
neXtProt	NX_O75607
Antibodypedia	NPM3 antibodies

PROTEIN BROWSER

NPM3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPM3-001 ENSP00000359128 ENST00000370110	O75607 [Direct mapping] Nucleoplasmin-3 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0009303 [rRNA transcription] GO:0044822 [poly(A) RNA binding] Show all	178 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.