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CPEB3

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GENERAL INFORMATION

Gene name

 CPEB3

Gene description

 Cytoplasmic polyadenylation element binding protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the intermediate filaments & nuclear bodies.

RNA cell category

 Cell line enhanced (Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Nuclear bodies (approved), Intermediate filaments (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA059056
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the intermediate filaments & nuclear bodies.

Main location

 Nucleoplasm (approved)

Additional location

 Nuclear bodies (approved), Intermediate filaments (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA059056 HaCaT Nucleoplasm
HPA059056 RH-30 Nucleoplasm
Nuclear bodies
Intermediate filaments Spatial
HPA059056 U-2 OS Nucleoplasm
Nuclear bodies

GENE INFORMATION

Gene name

 CPEB3 (HGNC Symbol)

Synonyms

 KIAA0940

Description

 Cytoplasmic polyadenylation element binding protein 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q23.32

Chromosome location (bp)

 92046692 - 92291087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107864 (version 83.38)

Entrez gene

 22849

UniProt

 Q8NE35 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NE35

Antibodypedia

 CPEB3 antibodies

PROTEIN BROWSER
CPEB3-001
CPEB3-002
CPEB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPEB3-001
ENSP00000398310
ENST00000412050
Q8NE35 [Direct mapping]
Cytoplasmic polyadenylation element-binding protein 3
Q5QP71 [Target identity:100%; Query identity:100%]
Cytoplasmic polyadenylation element binding protein 3, isoform CRA_a; cDNA FLJ61637, highly similar to Homo sapiens cytoplasmic polyadenylation element binding protein 3 (CPEB3), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000900 [translation repressor activity, nucleic acid binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0007616 [long-term memory]
GO:0008135 [translation factor activity, RNA binding]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030425 [dendrite]
GO:0035613 [RNA stem-loop binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043005 [neuron projection]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0048167 [regulation of synaptic plasticity]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0060998 [regulation of dendritic spine development]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061158 [3'-UTR-mediated mRNA destabilization]
GO:0071230 [cellular response to amino acid stimulus]
GO:0097440 [apical dendrite]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:1900248 [negative regulation of cytoplasmic translational elongation]
GO:1900365 [positive regulation of mRNA polyadenylation]
GO:1990124 [messenger ribonucleoprotein complex]
GO:2000766 [negative regulation of cytoplasmic translation]
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 684 aa
74.4 kDa 		No 0
CPEB3-002
ENSP00000265997
ENST00000265997
Q8NE35 [Direct mapping]
Cytoplasmic polyadenylation element-binding protein 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000900 [translation repressor activity, nucleic acid binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0007616 [long-term memory]
GO:0008135 [translation factor activity, RNA binding]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030425 [dendrite]
GO:0035613 [RNA stem-loop binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043005 [neuron projection]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0048167 [regulation of synaptic plasticity]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0060998 [regulation of dendritic spine development]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061158 [3'-UTR-mediated mRNA destabilization]
GO:0071230 [cellular response to amino acid stimulus]
GO:0097440 [apical dendrite]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:1900248 [negative regulation of cytoplasmic translational elongation]
GO:1900365 [positive regulation of mRNA polyadenylation]
GO:1990124 [messenger ribonucleoprotein complex]
GO:2000766 [negative regulation of cytoplasmic translation]
Show all
 698 aa
76 kDa 		No 0
CPEB3-201
ENSP00000482128
ENST00000614585
Q8NE35 [Direct mapping]
Cytoplasmic polyadenylation element-binding protein 3
Show all
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0000900 [translation repressor activity, nucleic acid binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0007616 [long-term memory]
GO:0008135 [translation factor activity, RNA binding]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030425 [dendrite]
GO:0035613 [RNA stem-loop binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043005 [neuron projection]
GO:0043022 [ribosome binding]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0048167 [regulation of synaptic plasticity]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0060998 [regulation of dendritic spine development]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061158 [3'-UTR-mediated mRNA destabilization]
GO:0071230 [cellular response to amino acid stimulus]
GO:0097440 [apical dendrite]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:1900248 [negative regulation of cytoplasmic translational elongation]
GO:1900365 [positive regulation of mRNA polyadenylation]
GO:1990124 [messenger ribonucleoprotein complex]
GO:2000766 [negative regulation of cytoplasmic translation]
Show all
 698 aa
76 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.